Members
Jason S. Carroll

Jason S. Carroll

Group Leader/Principal Investigator

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Jason S. Carroll

Jason is an Australian who completed a PhD in 2002 at the University of New South Wales and the Garvan Institute, Sydney, with Prof Robert Sutherland. He conducted postdoctoral work with Prof. Myles Brown at Dana-Farber Cancer Institute and Harvard Medical School, Boston, USA from 2002-2006. He has been running his own group at Cancer Research UK, Cambridge Institute and University of Cambridge since 2006. He is currently a senior group leader at Cancer Research UK, a Director of Research at University of Cambridge, a Fellow at Clare College and was elected an EMBO member in 2016. His lab is interested in understanding mechanisms of hormone-dependent cancer.

CV

Kelly Holmes

Kelly Holmes

 

Principal Scientific Officer

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Kelly Holmes

Kelly obtained her undergraduate degree from Leeds University and her PhD with Prof. Wolf Reik at the Babraham Institute and University of Cambridge in 2006. She was a postdoc in the Carroll lab and is now the Principal scientific officer in the lab. Amongst other things, Kelly is developing drugs against ER regulatory factors.

Caryn Ross-Innes

Caryn Ross-Innes

Principal Scientific Associate

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Caryn Ross-Innes

Caryn is from the sunny shores of Cape Town, South Africa.  She did her undergraduate degree at the University of Cape Town (UCT), specialising in biochemistry and microbiology and her honours and masters degree at UCT.  In 2007 she was awarded a Commonwealth Scholarship for her PhD studies and joined the laboratories of Jason Carroll and Duncan Odom.  Following graduation, Caryn joined Dr Rebecca Fitzgerald’s lab for a postdoc in Cambridge.

Stacey Jamieson

Stacey Jamieson

Postdoctoral Scientist

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Stacey Jamieson

Stacey completed her BA and BSc (Hons) degrees at Monash University. She then worked as a Research Officer for several years at Imperial College London. Stacey returned to Melbourne in 2007 to pursue a PhD under the supervision of Professor Peter Fuller at Prince Henry’s Institute of Medical Research. She joined the Carroll lab as a postdoc in March 2012. Her research interests lie in understanding the molecular mechanisms that contribute to the development of endocrine-related cancers.

Simon Johnston

Simon Johnston

Clinical PhD Student

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Simon Johnston

Simon is a medical oncology registrar at Addenbrookes Hospital, currently entering the final year of a PhD in the Carroll lab looking into functional regulators of the ER transcription factor, FoxA1. He has a particular interest in the translational aspects of the lab's work on FoxA1, specifically the process of drug discovery to target FoxA1 in hormone resistant breast cancer.

Rasmus Siersbaek

Rasmus Siersbaek

Postdoctoral Scientist

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Rasmus Siersbaek

Rasmus is from a small Danish island called Funen. He obtained his PhD in the lab of Susanne Mandrup at the University of Southern Denmark in 2012, where he stayed on as a postdoc. In 2015, he received a Novo Nordisk Foundation postdoc fellowship to join the Carroll lab. His main research interest is ER function in advanced stages of breast cancer, e.g. endocrine-resistance and metastasis.

Sankari Nagarajan

Sankari Nagarajan

Postdoctoral Scientist

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Sankari Nagarajan

Sankari got her Masters in Bio-Medical Science in Bharathidasan University, Trichy in south India. Then she moved to Germany with the German Academic Exchange Service (DAAD) scholarship for her PhD studies. She worked in Breast Cancer Epigenetics in the lab of Prof. Dr. Steven A Johnsen in Georg-August University, Goettingen and obtained her Dr. Rer. Nat (German equivalent of PhD) degree with the best PhD award in her institute. She joined the Carroll group in November 2015 with an interest in understanding the mechanisms of drug resistance in ER-positive breast cancers.

Rebecca Broome

Rebecca Broome

PhD Student

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Rebecca Broome

Rebecca did her undergraduate degree at the University of Manchester, studying Biomedical Sciences combined with a year working in industry. Following this she moved to Cambridge to work as a Research Assistant in the Department of Genetics, before starting her PhD in the Carroll lab in 2015.

Eva Papachristou

Eva Papachristou

PhD Student

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Eva Papachristou

Eva is a PhD student since January 2016 and also works as a research assistant in the proteomics core facility since February 2014. She studied Biochemistry and Biotechnology at the University of Thessaly in Greece and she received her Master’s degree in Molecular Medicine and Advanced Molecular Diagnostics at the Medical School of Athens in 2012. Her master's thesis was focused on the development of quantitative proteomic approaches for the detection of human papillomavirus (HPV) at the protein level in cervical samples. The mass spectrometry analysis of her thesis took place at the University of Southampton, UK where she received a Research Technician position in 2013. Her role was to accomplish the proteomic characterization of cancerous serum and tissue specimens using state of-the -art LC-MS methods.

Igor Chernukhin

Igor Chernukhin

Bioinformatician

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Igor Chernukhin

I have a mixed computational and biological background. I did my PhD in Biology in Novosibirsk, Russia in 1995 and moved to the University of Oxford for postdoctoral research in 1996. Since 2001 I continued my postdoctoral study at the University of Essex and later, in 2004, I became a member of the core service in the Department of Biological Sciences where I provided proteomics and bioinformatics support. I joined the Carroll lab as bioinformatician in September 2015.

Silvia Glont

Silvia Glont

PhD Student

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Silvia Glont

Silvia joined the Carroll Lab in 2015 for her PhD project, characterising mutations in transcription factors associated with breast cancer. Her career journey began at ‘Ovidius’ University in Romania, where she completed her MPharm in 2012. She then undertook an MSc in Molecular Pathology and Toxicology, at the University of Leicester. Her dissertation project focused on the influence of mutated MAPK pathway on Vitamin D3 in melanoma. Afterwards, she worked as a Research Assistant in the Caldas Lab at Cancer Research UK- Cambridge Institute, developing histological-based methods for breast tumour classification.

Sanjeev Kumar

Clinical PhD Student in Carroll Lab

 

Profile

Sanjeev is a medical oncologist with the Royal Australian College of Physicians (2015). He completed his undergraduate medical studies in sunny Sydney at the University of New South Wales (2006), having grown up in a tiny country town called Canowindra. He moved to the UK in 2015 to work at Addenbrooke’s Hospital as a phase 1 clinical trials fellow, following previous clinical interests in melanoma and immunotherapeutics in Australia. He is now undertaking a full time PhD in Jason Carroll’s laboratory at the CRUK CI having been awarded a Cambridge Cancer Centre Clinical Research Fellowship, where he will be coordinating a pre-operative therapeutic ‘window’ study in postmenopausal women with early breast cancer translating the lab’s work into cross-talk between the nuclear receptors ERα and PR in ER-positive breast cancer.

Alasdair Jubb

Visiting Scientist in Carroll Lab

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Alasdair studied medicine in Cambridge and Edinburgh, and then began his training in Anaesthesia and Critical Care Medicine in Exeter. He returned to Edinburgh to undertake his PhD jointly at the Roslin Institute and the MRC Human Genetics Unit supervised by David Hume and Wendy Bickmore, studying the genomic effects of glucocorticoids on macrophages.  Alasdair came to Cambridge in 2015 from a Clinical Lecturer post at the University of Edinburgh. He has joined the Carroll group at the CRUK Cambridge Institute to further his study of how nuclear hormone receptors and their ligands bring about both acute and long-term genomic changes.

 

Further information about Alasdair can be found here.

 

 

Affiliate Members
Wayne Tilley

Wayne Tilley

Visiting Scientist


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Wayne Tilley

Wayne Tilley is Director of the Dame Roma Mitchell Cancer Research Laboratories and the Adelaide Prostate Cancer Research Centre, University of Adelaide, South Australia. His main research interests encompass the molecular mechanisms of development and progression of breast and prostate cancer and resistance to hormonal therapies used in the treatment of both cancers. While on sabbatical in the Carroll lab he is pursuing a better understanding of androgen receptor action in both breast and prostate cancer by using new genomic, proteomic and bioinformatics approaches developed by the Carroll lab. He convenes the PacRim Breast and Prostate Cancer meeting series and has a keen interest in wine!

Theresa Hickey

Theresa Hickey

Visiting Scientist


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Theresa Hickey

Dr Theresa Hickey is interested in the role of the androgen receptor (AR) in the biology and pathology of female tissues. She received a PhD from the University of Adelaide, South Australia, in 2006 on the theme of AR action in polycystic ovary syndrome (PCOS), a common cause of female infertility and metabolic dysfunction that is associated with androgen excess. Dr Hickey did postdoctoral studies in the Dame Roma Mitchell Cancer Research Laboratories at the University of Adelaide with research focussed on the role of AR in breast cancer (see a review by Hickey et al, Molecular Endocrinology, August 2012). Today she heads the Breast Cancer Research Group at the Dame Roma Laboratories and is currently a visiting scientist at Cancer Research UK, Cambridge Research Institute in the laboratory of Dr Jason Carroll, where she is engaged in exploring genome-wide AR binding events in different breast cancer contexts.

Andrew Holding

Andrew Holding

Senior Research Associate - Markowetz group.


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Andrew Holding

Andrew is a Senior Research Associate and Fellow of Downing College, Cambrige. Andrew is responsible for the experimental research programme of the Markowetz group and is working with the Carroll lab to obtain evidence on the dynamic nature of the oestrogen receptor in breast cancer tumour cells. This will provide the basis for the development of a quantitative model and facilitate our understanding of what drives this process. In the long term, the model could be used to predict the effects of perturbing components of the pathway with drugs and potentially lead to improved combinatorial treatment regimes.

Luke Selth

Luke Selth

Visiting Scientist


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Luke Selth

Dr Luke Selth’s research interests are focussed on gaining a better understanding of the mechanisms underlying prostate cancer progression and metastasis, with specific emphasis on the roles of the androgen receptor and microRNAs in these processes. He received his PhD from the University of Adelaide, South Australia, in 2005 and subsequently undertook post-doctoral studies at Cancer Research UK’s London Research Institute at Clare Hall, where, under the guidance of Dr Jesper Svejstrup, he studied the mechanisms by which chromatin is modified to facilitate transcription elongation. He subsequently returned to Adelaide in 2009 and now is Head of Prostate Cancer Research at the Dame Roma Mitchell Cancer Research Laboratories at the University of Adelaide, working closely with Professor Wayne Tilley. Dr Selth is visiting Dr Jason Carroll’s laboratory from April-August 2016 on an Endeavour Research Fellowship: during this period, he will be exploring the function and clinical relevance of novel androgen receptor coregulators in advanced prostate cancer.

Former Members
Rosalind Launchbury

Rosalind Launchbury

Scientific Officer


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Rosalind Launchbury

Rosalind has a degree in Human Biology from Oxford Brookes University and an MSc in Reproductive biology from the University of Edinburgh.  She has worked as a Scientific Officer in the Carroll lab for just over 2 years, managing the lab and carrying out experimental work for collaborative projects.

Gordon Brown

Gordon Brown

Senior Scientific Officer/Bioinformatician


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Gordon Brown

Gord began his career as a programmer when Fortran was still cool and the Internet hadn't been invented yet.  He moved into computational biology in 1998, and now spends his time striving to transmute the base metal of high-throughput sequencing data into research gold.

 

Toni Hurtado

Toni Hurtado

(former postdoc)


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Toni Hurtado

Toni’s work has been centered on the study of hormone-dependent cancer. In his Masters degree he studied the effects of dietary factors in breast cancer initiation and progression at Autonomous University of Barcelona (Spain). His PhD was conducted at the Vall-Hebron Research Institute of Barcelona (Spain). Toni was a postdoc in the Carroll lab from 2007-2011 and is now an independent group leader at the Norwegian Centre of Molecular Medicine (NCMM-EMBL).

Vasiliki Theodorou

Vasiliki Theodorou

Postdoctoral Scientist


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Vasiliki Theodorou

Vasiliki (Vasso) completed her undergraduate degree at Aristotle University of Thessaloniki, Greece and her PhD with Dr. John Hilkens, NKI, Amsterdam in 2007. She joined the Carroll lab as a postdoc in 2007 and she is interested in understanding how ER associated factors, particularly GATA3, impact ER biology and tumour outcome in breast cancer.

Aisling Redmond

Aisling Redmond

Postdoctoral Scientist


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Aisling Redmond

Aisling completed her undergraduate degree from Trinity College Dublin in 1999.  After three years pursuing non-scientific interests she saw the light again and returned to postgraduate studies at Dublin City University for her PhD. She was a postdoctoral research fellow at the Royal College of Surgeons in Ireland.  Aisling was awarded an IRCSET Inspire Marie Curie Fellowship to join the Carroll lab at the end of 2009 and has been examining the role of a number of chromatin proteins in estrogen receptor driven breast cancer. 

 

Aurelien Serandour

Aurelien Serandour

Postdoctoral Scientist


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Aurelien Serandour

Aurelien conducted his PhD with Dr. Jerome Eeckhoute and Dr. Raphael Metivier at the University of Rennes 1, France. He joined the Carroll lab as a postdoc in January 2012. He is currently working on transcription factors implicated in breast cancer.

 

Jessica Robinson

Jessica Robinson

PhD student


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Jessica Robinson

Jess completed her undergraduate degree in Biochemistry and Medical Biochemistry at University of Leeds. She spent time in the sunshine at the Mayo Clinic, Jacksonville, Florida with Dr Elliot Richeslon and then Dr Evette Radisky. In 2009, Jess joined Cancer Research UK as a PhD student in the laboratories of Dr Jason Carroll and Professor David Neal. She is studying the dynamic crosstalk between the androgen receptor and estrogen receptor in breast cancer.  

 

 

Hisham Mohammed

Hisham Mohammed

PhD student


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Hisham Mohammed

Hisham is from Kerela, India. He did his undergraduate training in Bangalore, India and then moved to Dundee to do an Msc in biotechnology. He then worked with Prof. Gill Murphy's group at the CRUK, before joining the Carroll group for his PhD. He is currently focusing on developing methods to integrate high throughput sequencing and proteomics approaches to study transcription factor complexes.  Hisham has moved on to Wolf Reik's lab at the Babraham Institute, and can be reached at Hisham.Mohammed@babraham.ac.uk.

 

 

Kamila Jozwik

Kamila Jozwik

PhD student


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Kamila Jozwik

Kamila obtained her B.Sc in biotechnology from the University of Warsaw, Poland. Following this, she did research projects and courses at Cambridge, Oxford, Aarhus and Harvard. Kamila then did a MPhil in Biological Sciences in Cambridge in Prof Steve Jackson’s lab. Her research interests are still evolving but include mechanisms of cancer (Estrogen Receptor transcription  specifically) and interdisciplinary approaches for understanding neuroscience. She is interested in travelling, piano, dance and whatever moves her.

 

 

Kam Zaki

Kam Zaki

Medical Fellow


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Kam Zaki

Kam is a medical oncology trainee in Cambridge. His goal is to learn scientific methodology and understand cancer biology, in order to solve clinical challenges that he sees in oncology clinics. His aim is to be able to introduce novel therapeutics to cancer patients through hypothesis-driven clinical trials.

 

 

Wilbert Zwart

Wilbert Zwart

(former postdoc)


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Wilbert Zwart

Wilbert is a dutch scientist who obtained his PhD with Prof. Rob Michalides at the NKI, Amsterdam. Wilbert joined the Carroll lab as a postdoc from 2009-2011 and has moved back to Amsterdam to run his own research lab at the NKI. His interest is in the genomic and molecular understanding of breast cancer and drug resistance.

Dominic Schmidt

Dominic Schmidt

(former PhD student)


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Dominic Schmidt

Dominic graduated from the Freie Universität Berlin in 2007 and did his
German Biochemistry Diplom Degree Thesis at the Max Planck Institute for
Molecular Genetics (Berlin, Germany). Currently, he is reading for a PhD at the University of Cambridge in Duncan Odom's and Jason Carroll's lab. His research is focused on transcriptional regulation and genome evolution. Dominic is a member of Darwin College and enjoys rowing in his free time with the Cantabrigian Rowing Club.

Adam Nelson

Adam Nelson

Clinical PhD Student


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Adam Nelson

Adam is a registrar in urological surgery. He completed his medical training and MRes in Biomedical and Life Sciences at the University of Glasgow before moving to Cambridge to pursue surgical training. He is currently working in the Carroll lab and Academic Urology Group, University of Cambridge to investigate the role and mechanisms of the estrogen receptor in the development and progression of prostate cancer.

Karan Wadhwa

Karan Wadhwa

PhD student


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Karan Wadhwa

My undergraduate years were spent in the University of Nottingham Medical School where I undertook my Bachelors in Medical Science and Bachelors in Medicine and Surgery, as well as gaining my membership to the Royal College of Surgeons. In Cambridge, I am an honorary urology speciality trainee at registrar level doing my PhD funded by the Medical Research Council on their Clinical Research Training Fellowship scheme. I have a keen interest in diagnostic urology and my academic research focuses on a potential novel blood marker of prostate cancer.

Geetha Sankaranarayanan

Geetha Sankaranarayanan

Scientific Officer


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Geetha Sankaranarayanan

I hold a Bachelors degree in Microbiology and Masters degree in Biotechnology. I have been working in the Carroll group since April 2014 as a research assistant, managing the lab and carrying out experimental work on ongoing projects in the lab, as well as collaborative projects with other groups.

Sarah Jurmeister

Sarah Jurmeister

PhD student


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Sarah Jurmeister

Sarah obtained her B.Sc. in molecular cell biology from the University of Heidelberg. During this time, she became fascinated by cancer biology and decided to learn more about this topic during her master’s studies, which she completed at the German Cancer Research Centre. In 2011, she started her PhD at the Cambridge Research Institute. Sarah is interested in identifying kinases that could potentially serve as therapeutic targets in prostate cancer, and in understanding how they contribute to tumour development and progression.

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