Included are binding co-ordinates for various genomic datasets from some of the lab publications. All co-ordinates are Hg18 (March 2006) version of the human genome.
Hurtado, Nature, 2008
This paper includes the last ChIP-chip experiment we ever did. It is ER ChIP-chip data from MCF-7 breast cancer cells treated with estrogen
Link to dataset 1: downloadable files:
Ross-Innes, Genes Dev, 2010
This paper includes ER ChIP-seq data, RAR-alpha ChIP-seq data and ER-RAR-alpha Re-ChIP-seq data from MCF-7 breast cancer cells
Link to dataset 2: downloadable files:
ER and RARA ReChIP regions
ER binding events
RARA binding events
Hurtado, Nature Genetics, 2011
This manuscript includes ER ChIP-seq data from MCF-7, T47-D and ZR75-1 breast cancer cells, plus FoxA1 ChIP-seq data from MCF-7, T47-D and ZR75-1 cells. Also included in ER ChIP-seq in a Tam-R (tamoxifen resistant) MCF-7 derivative. In Tam-R cells, ER ChIP-seq was conducted under hormone-deprived conditions and treated with vehicle or tamoxifen. FAIRE data (nucleosome depleted regions) is provided. FAIRE was conducted in hormone deprived MCF-7 cells, transfected with siControl or siFoxA1 and treated with vehicle or estrogen.
Link to dataset 3: downloadable files:
Holmes, PNAS, 2011
This dataset represents ER binding events that occur when TLE1 is silenced (TLE1 independent) and ER binding events that only occur in the presence of TLE1 (TLE1 dependent) in MCF-7 cells
Link to dataset 4: downloadable files (human genome version hg18):
TLE1 dependent ER binding
TLE1 independent ER binding
Peak sets for individual libraries (human genome version hg18):
Links to raw data at ArrayExpress:
-- FoxA1 ChIP
-- ER ChIP (siLuc and siTLE1)
Robinson, EMBO, 2011
This paper focuses on AR in MDA-MB-453 breast cancer cells. The data includes AR and FoxA1 ChIP-seq data from MDA-MB-453 breast cancer cells, which are ER- but AR+
Link to dataset 5: downloadable files:
LNCaP_ AR binding
Zwart, EMBO, 2011
This paper provides ChIP-seq data for the SRC co-factors and p300/CBP family members. SRC1, SRC2, SRC3, p300 and CBP ChIP-seq were conducted in hormone deprived MCF-7 cells that were treated with vehicle or estrogen for 3hr.
Link to dataset 6: downloadable files:
Ross-Innes, Nature, 2012
"Differential oestrogen receptor binding is associated with clinical outcome in breast cancer."
This paper describes the binding patterns of ER in tumours of varying clinical outcome. The following data files provide the binding loci that are associated with poor and good outcomes, and those which are conserved in both cases.
Poor outcome regions
Good outcome regions